Analysis of the genetic predisposition to develop a Myocardial Infarction in a sample of Moroccan patients

Myocardial infarction (MI) is a multifactorial coronary artery disease influenced by environmental and genetic factors. Being one of the leading causes morbidity mortality in developed countries, it becoming national health concern developing countries such as Morocco. In present work, we aim to study association between 4 Alu polymorphisms (ACE, FXIII-B, TPA-25 APOA1) genes risk MI Moroccan population. 210 patients with history myocardial 203 healthy individuals were included this study. The determined PCR technique followed direct electrophoresis. Only I / I_APOA1 genotype showed significant (p˂0.001; OR = 2.171), while genotypes carrying D allele (D or D) protective effect (p <0.001; 0.46). Patients presenting an high level triglycerides 0.020, 2.14)), well LDLs 0.035, 2, 00). Subjects dyslipidemia hyperglycemia are more likely develop MI, those D_APOA1 cholesterol.